K63 Ubiquitin Linkage ELISA Kit (Chain Selective)

The Ubiquitin Proteasome System (UPS) is a dynamic process involved in various cellular functions, including cell signaling, DNA repair, and proteasomal degradation. Ubiquitin can form diverse chains on its seven lysine residues, with K48 and K63-linked polyubiquitination being a crucial post-translational modification. While K48 polyubiquitination predominantly drives protein degradation and maintains cellular homeostasis, K63 linked polyubiquitination plays a pivotal role in various cellular processes, primarily associated with trafficking, signaling pathways, DNA repair mechanisms, and the regulation of protein-protein interactions. Lifesensors’ K63 Ubiquitin Linkage ELISA Kit enables relative and absolute quantitation of K63 ubiquitination on target proteins in cellular and tissue lysates under various treatments and conditions.