IWP-2

• GMP format available

IWP-2 is a potent, cell-permeable, and selective inhibitor of Wnt processing and secretion. It works by blocking the activity of Porcupine (Porcn), a membrane-bound O-acyltransferase essential for the palmitoylation and secretion of Wnt proteins. This inhibition disrupts the Wnt/β-catenin signaling pathway, which is crucial for various cellular processes, including cell proliferation, differentiation, and migration.

Key features and applications include:

• Stem Cell Research: IWP-2 is used to study the differentiation of human pluripotent stem cells (hPSCs) into various cell types, including cardiomyocytes and lung epithelial cells.
• Cancer Research: It is employed to investigate the role of Wnt signaling in cancer progression and tumorigenesis.
• Developmental Biology: Researchers use IWP-2 to study Wnt signaling pathways during embryonic development and organogenesis.
• Regenerative Medicine: IWP-2 is used in protocols to reprogram human somatic cells into induced pluripotent stem cells (iPSCs), aiding in the development of regenerative therapies.

Relevant disease states include:

• Cancer: By inhibiting Wnt signaling, IWP-2 is relevant in research focused on cancers where Wnt signaling is dysregulated.
• Bone Disorders: It is relevant in research on bone diseases, as Wnt signaling is crucial for bone formation and homeostasis.