Itraconazole

Inhibits 14-α demethylase, a cytochrome P-450 enzyme, thus blocking conversion of lanosterol to ergosterol. Itraconazole inhibits glioblastoma cell proliferation in vitro and in vivo, and stimulates autophagic progression through inhibition of cholesterol trafficking from late endosomes and lysosomes to the plasma membrane. Binds Smoothened (SMO) via a mechanism distinct from that of cyclopamine, inhibiting the Hedgehog pathway. Also inhibits angiogenesis via blocking the binding of VEGF to VEGFR2.