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Isoxanthohumol

ALX-350-279

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Phytoestrogen

Racemic mixture of (+/-)-Isoxanthohumol.
Prenylated flavonoid. Phytoestrogen. Induces apoptosis in mature adipocytes.

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Product Details

Alternative Name	(±)-Isoxanthohumol
Appearance	Off-white to yellow powder.
CAS	521-48-2
Formula	C₂₁H₂₂O₅
Identity	Determined by 1H-NMR, 13C-NMR and LC-MS.
MW	354.4
Purity	≥98% (1H-NMR)
Solubility	Soluble in DMSO (50mg/ml) or methanol (50mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibition of TGF-beta signaling, vasculogenic mimicry and proinflammatory gene expression by isoxanthohumol: A. Serwe, et al.; Invest. New Drugs 30, 898 (2012), Abstract
Inhibitors of hyaluronan export from hops prevent osteoarthritic reactions: D. Stracke, et al.; Mol. Nutr. Food Res. 55, 485 (2010), Abstract
The Impact of a Xanthohumol-Enriched Hop Product on the Behavior of Xanthohumol and Isoxanthohumol in Pale and Dark Beers:A Pilot Scale Approach: P.J. Magalhaes, et al.; J. Inst. Brew. 114, 246 (2008), Full Text
Endocrine Disrupting Compounds (EDCs): Disrupting Human Endocrine Physiology and the Intricate Reproductive Balance: S.A. Sidiropoulos; UTMJ 85, 76 (2008), Abstract
Effect of xanthohumol and isoxanthohumol on 3T3-L1 cell apoptosis and adipogenesis: J.Y. Yang, et al.; Apoptosis 12, 1953 (2007), Abstract
The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine: S. Possemiers, et al.; J. Nutr. 136, 1862 (2006), Abstract
Identification of human hepatic cytochrome P450 enzymes involved in the metabolism of 8-prenylnaringenin and isoxanthohumol from hops (Humulus lupulus L.): J. Guo, et al.; Drug Metab. Dispos. 34, 1152 (2006), Abstract
Metabolism of xanthohumol and isoxanthohumol, prenylated flavonoids from hops (Humulus lupulus L.), by human liver microsomes: D. Nikolic, et al.; J. Mass Spectrom. 40, 289 (2005), Abstract
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!: J.F. Stevens & J.E. Page; Phytochemistry 65, 1317 (2004), (Review), Abstract
Inhibition of endothelial cell functions by novel potential cancer chemopreventive agents: E. Bertl, et al.; BBRC 325, 287 (2004), Abstract

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Isoxanthohumol

ALX-350-279

Product Details

Handling & Storage

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