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Isovelleral

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TRPV1 antagonist

Antagonist with different binding profiles towards the vanilloid receptor 1 (TRPV1).
Activator of TRPA1

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Appearance	White to off-white crystalline solid.
CAS	37841-91-1
Couple Target	TRP channel
Couple Type	Inhibitor
Formula	C₁₅H₂₀O₂
MW	232.3
Purity	≥99%
Solubility	Soluble in organic solvents.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

TRPA1 mediates the noxious effects of natural sesquiterpene deterrents: J. Escalera, et al.; J. Biol. Chem. 283, 24136 (2008), Abstract
Pharmacology of vanilloids at recombinant and endogenous rat vanilloid receptors: V. Ralevic, et al.; Biochem. Pharmacol. 65, 143 (2003), Abstract
The preparation and bioactivities of (-)-isovelleral: M. Jonassohn, et al.; Bioorg. Med. Chem. 5, 1363 (1997), Abstract
The stimulation of capsaicin-sensitive neurones in a vanilloid receptor-mediated fashion by pungent terpenoids possessing an unsaturated 1,4-dialdehyde moiety: A. Szallasi, et al.; Br. J. Pharmacol. 119, 283 (1996), Abstract
Comparison of the antimicrobial and cytotoxic activities of twenty unsaturated sesquiterpene dialdehydes from plants and mushrooms: H. Anke & O. Sterner; Planta Med. 57, 344 (1991), Abstract
Fungal extractives I. structure of a sesquiterpene dialdehyde from Lactarius by computer simulation of the nmr spectrum: G. Magnusson, et al.; THL 13, 1105 (1972), (Isolation)

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