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Isotetrandrine

BML-G520

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Phospholipase inhibitor

Isotetrandrine is a biscoclaurine alkaloid which inhibits G-protein mediated activation of phospholipase A₂ (PLA₂) but not phospholipase C (PLC) or D (PLD). Cell permeable.

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Product Details

Alternative Name	Berbamine methyl ether, 6,6′,7,12-Tetramethoxy-2,2′-dimethyl-berbaman
Appearance	Off-white solid.
CAS	477-57-6
Couple Target	Phospholipase, PLA
Couple Type	Inhibitor
Formula	C₃₈H₄₂N₂O₆
MW	622.7
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (20mg/ml) or ethanol (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibition of membrane tubule formation and trafficking by isotetrandrine, an antagonist of G-protein-regulated phospholipase A2 enzymes: D. Chan, et al.; Mol. Biol. Cell. 15, 1871 (2004), Abstract
Biscoclaurine alkaloids inhibit receptor-mediated phospholipase A2 activation probably through uncoupling of a GTP-binding protein from the enzyme in rat peritoneal mast cells: S. Akiba, et al.; Biochem. Pharmacol. 44, 45 (1992), Abstract
Tetrandrine and isotetrandrine, two bisbenzyltetrahydroisoquinoline alkaloids from Menispermaceae, with rat uterine smooth muscle relaxant activity: P. D’Ocón, et al.; J. Pharm. Pharmacol. 44, 579 (1992), Application(s): inhibition of uterine contraction, Abstract
Suppressive effect of biscoclaurine alkaloids on agonist-induced activation of phospholipase A2 in rabbit platelets: T. Hashizume, et al.; Biochem. Pharmacol. 41, 419 (1991), Abstract
Total syntheses of optically active natural isotetrandrine, phaeanthine and tetrandrine: Y. Inubushi, et al.; Tetrahedron Lett. 30, 3399 (1968), Abstract

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Isotetrandrine

BML-G520

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