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- First to market active Irisin
- Multifunctional protein validated for activity assay, ELISA, SDS-PAGE and Western blot
- Important regulatory protein for metabolism and neurogenesis
Irisin is a hormone that is involved in converting white adipose tissue into brown adipose tissue after physical exercise. It is formed after the membrane bound protein fibronectin type III domain containing protein 5 (FNDC5) is cleaved resulting in a secreted protein. FNDC5 is found in muscle tissue and is activated during physical exertion via the protein PGC1a. Soluble Irisin has also been shown to up regulate UCP-1 gene expression in mice. UCP-1 is a mitochondrial transporter protein and a marker of brown adipose tissue conversion. This suggests that Irisin plays an important role in energy regulation and furthermore may lead to improvements in glucose regulation, insulin sensitivity, hypertension, and obesity.
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Figure 1: Coomassie stained SDS-PAGE analysis of Irisin (human) (rec). Lane 1: Molecular weight marker, Lane 2: 1µg Irisin.
Figure 2: Western blot analysis of Irisin (human) (rec) against mouse anti-flag antibody. Lane 1: Molecular weight marker, Lane 2: 0.1µg Irisin.
Figure 3: Western blot analysis of Irisin (human) (rec) against rabbit anti-FNDC5 antibody. Lane 1: Molecular weight marker, Lane 2: 0.1µg Irisin.
Figure 4: Stimulation of UCP-1 after treatment with Irisin (human) (rec). 3T3L1 cells were treated with or without 2µg/ml Irisin. After 48 hours the cells were lysed, normalized to total protein, and run on an SDS-PAGE. Gels were transferred to nitrocellulose and blotted against rabbit anti-UCP-1 antibody.
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RUO – Research Use Only |
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