Home Shop Irinotecan . hydrochloride . trihydrate

Irinotecan . hydrochloride . trihydrate

ALX-430-139

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Topoisomerase I inhibitor

A member of the camptothecin drug family, and an inhibitor of the nuclear enzyme topoisomerase I, which is involved in cellular DNA replication and transcription. During replication topoisomerase I mediates the relaxation of super coiled DNA, and its inhibition results in breakage of the DNA chain and likely induce apoptosis. Irinotecan is, therefore, an attractive target for anticancer drug development. Currently it is used for the treatment of small cell lung cancer and advanced colorectal cancer.

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Product Details

Alternative Name	Camptosar, 7-ethyl-10-hydroxycamptothecin, CPT-11
Appearance	White solid.
CAS	136572-09-3
Couple Target	Topoisomerase
Couple Type	Inhibitor
Formula	C₃₃H₃₈N₄O₆ . HCl . 3H₂O
Identity	Determined by NMR.
MI	14: 5091
MW	586.7 . 36.5 . 54.0
Purity	≥97% (HPLC)
RTECS	DW1061000
Solubility	Slightly soluble in methanol or water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Common variants of Drosophila melanogaster Cyp6d2 cause camptothecin sensitivity and synergize with loss of Brca2: Thomas, A. M., Hui, C., et al.; G3 (Bethesda) 3, 91 (2013), Abstract
Irinotecan activates p53 with its active metabolite, resulting in human hepatocellular carcinoma apoptosis: Y. Takeba, et al.; J. Pharmacol. Sci. 104, 232 (2007), Abstract
Therapeutic advances in small cell lung cancer: F.P. Worden and G.P. Kalemkerian; Expert Opin. Investig. Drugs 9, 565 (2000), Abstract
Human DNA-Topoisomerases – Diagnostic and Therapeutic Implications for Cancer: U. Kellner, et al.; Onkologie 23, 424 (2000), Abstract
The role of irinotecan in colorectal cancer: L.B. Saltz; Curr. Oncol. Rep. 1, 155 (1999), Abstract
Induction of tumor necrosis factor by a camptothecin derivative, irinotecan, in mice and human mononuclear cells: S. Goto, et al.; Anticancer Res. 16, 2507 (1996), Abstract

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Irinotecan . hydrochloride . trihydrate

ALX-430-139

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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