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IQ-1

BML-WN115

1 citation

  • BML-WN115-0005   —   5 mg
    $130.00
  • BML-WN115-0025   —   25 mg
    $595.00

IQ-1 in conjunction with Wnt3a has been shown to be sufficient to maintain murine embryonic stem cell proliferation in the absence of serum. Binds to the PR72/PR130 subunit of protein phosphatase PP2A preventing β-catenin from switching co-activator usage from CBP to p300 leading to an increase in β-catenin/CBP-driven transcription at the expense of β-catenin/p300-driven transcription. Upregulates expression of Oct4 and Sox2 transcription factors.

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Regulatory Status

RUO – Research Use Only