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Calcium ionophore
Potent and highly selective calcium ionophore. Ca2+/ionomycin complex forms between pH 7-9.5 which has intense UV absorption. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest at G1 phase. Useful tool for increasing intracellular Ca2+ concentration. More effective than A23187. Non fluorescent. Has been used at 4nM and 2-4µM (whole cells).
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Product Details
| Appearance |
Waxy yellow to colorless material |
|---|---|
| CAS |
56092-81-0 |
| Formula |
C41H72O9 |
| MW |
709.0 |
| Purity |
≥90% (HPLC, TLC) |
| Solubility |
Soluble in DMSO or methanol. |
| Source |
Isolated from Streptomyces conglobatus. |
Handling & Storage
| Use/Stability |
As indicated on product label or CoA when stored as recommended. Stock solutions are stable for 1 year when stored at +4°C. |
|---|---|
| Handling |
Protect from light. Keep under inert gas. |
| Long Term Storage |
+4°C |
| Shipping |
Ambient Temperature |
| Regulatory Status |
RUO – Research Use Only |
|---|
- The endoplasmic reticulum pool of Bcl-xL prevents cell death through IP3R-dependent calcium release: R. Gadet, et al.; Cell Death Discov. 10, 346 (2024), Abstract
- TMCO1 is upregulated in breast cancer and regulates the response to pro-apoptotic agents in breast cancer cells: Bong, A. H. L., Robitaille, M., et al.; Cell Death Discov. 10, 421 (2024), Application(s): ICC-IF, Abstract
- Impaired cerebral microvascular endothelial cells integrity due to elevated dopamine in myasthenic model: Y. Hao, et al.; J. Neuroinflammation 21, 10 (2024), Application(s): Treatment of primary rat splenocytes, Abstract — Full Text
- Increased matrix stiffness suppresses ATP-induced sustained Ca2+ influx in MDA-MB-231 breast cancer cells: C.L. So, et al.; Cell Calcium 104, 102569 (2022), Abstract
- GARP Regulates the Immune Capacity of a Human Autologous Platelet Concentrate: Trzeciak, E. R., Zimmer, N., et al.; Biomedicines 10, (2022), Abstract
- Up-regulation of BTN3A1 on CD14+ cells promotes Vγ9Vδ2 T cell activation in psoriasis: J. Zhou, et al.; PNAS 119, e2117523119 (2022), Abstract
- The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses: M.E. Cook, et al.; Sci. Immunol. 7, eabo0981 (2022), Abstract
- Platelet-Derived GARP Induces Peripheral Regulatory T Cells-Potential Impact on T Cell Suppression in Patients with Melanoma-Associated Thrombocytosis: Zimmer, N., Krebs, F. K., et al.; Cancers (Basel) 12, (2020), Abstract
- Mesenchymal stem cells induced CD4+ T cell apoptosis in treatment of lupus mice: S. Huang, et al.; Biochem. Biophys. Res. Commun. 507, 30 (2018), Abstract
- TRESK background potassium channel is not gated at the helix bundle crossing near the cytoplasmic end of the pore: Lengyel, M., Czirják, G., et al.; PLoS One 13, e0197622 (2018), Abstract
- Evaluation of a combination lymphocyte apoptosis model” to predict survival of sepsis patients in an intensive care unit”””: W. Jiang, et al.; BMC Anesthesiol. 18, 89 (2018), Abstract — Full Text
- CD19 and BAFF-R can signal to promote B-cell survival in the absence of Syk: Hobeika, E., Levit-Zerdoun, E., et al.; EMBO J. 34, 925 (2015), Abstract
- Olfactory ecto-mesenchymal stem cells possess immunoregulatory function and suppress autoimmune arthritis: K. Rui, et al.; Cell. Mol. Immunol. 13, 401 (2015), Application(s): Flow cytometric analysis in mouse cells, Abstract
- Chrysin suppresses human CD14+ monocyte-derived dendritic cells and ameliorates experimental autoimmune encephalomyelitis: K. Zhang, et al.; J. Neuroimmunol. 288, 13 (2015), Application(s): Intracellular cytokine staining, Abstract
- Puerarin attenuates smoke inhalation injury by regulation of Th1/Th2 expression and inhibition of Th17 cells in rats: F. Zhang, et al.; Int. Immunopharmacol. 28, 546 (2015), Application(s): Cell culture , Abstract
- Inactivation of Notch signaling reverses the Th17/Treg imbalance in cells from patients with immune thrombocytopenia: Yu, S., Liu, C., et al.; Lab. Invest. 95, 157 (2015), Abstract
- The Profile of T Helper Subsets in Bone Marrow Microenvironment Is Distinct for Different Stages of Acute Myeloid Leukemia Patients and Chemotherapy Partly Ameliorates These Variations: T. Tian, et al.; PLoS One 10, e0131761 (2015), Application(s): Cell Culture, Abstract — Full Text
- Expression of Fgf23 in activated dendritic cells and macrophages in response to immunological stimuli in mice: Masuda, Y., Ohta, H., et al.; Biol. Pharm. Bull. 38, 687 (2015), Abstract
- Evaluation of suppressive and pro-resolving effects of EPA and DHA in human primary monocytes and T-helper cells: Jaudszus, A., Gruen, M., et al.; J. Lipid Res. 54, 923 (2013), Abstract
- Non-THC cannabinoids inhibit prostate carcinoma growth in vitro and in vivo: pro-apoptotic effects and underlying mechanisms: De Petrocellis, L., Ligresti, A., et al.; Br. J. Pharmacol. 168, 79 (2013), Abstract
- Air bubble contact with endothelial cells in vitro induces calcium influx and IP3-dependent release of calcium stores: Sobolewski, P., Kandel, J., et al.; Am. J. Physiol. Cell Physiol. 301, C679 (2011), Abstract
- Tumor stroma-derived Wnt5a induces differentiation of basal cell carcinoma of Ptch-mutant mice via CaMKII: Nitzki, F., Zibat, A., et al.; Cancer Res. 70, 2739 (2010), Abstract
- Ionomycin downregulates beta-catenin/Tcf signaling in colon cancer cell line: C.H. Park, et al.; Carcinogenesis 26, 1929 (2005), Abstract
- ctivation of stress response by ionomycin in rat hepatoma cells: A. S. Sreedhar & U. K. Srinivas; J. Cell. Biochem. 86, 154 (2002), Abstract
- Differential activation of a calcium-dependent endonuclease in human B lymphocytes. Role in ionomycin-induced apoptosis: K.M. Aagaard-Tillery & D.F. Jelinek; J. Immunol. 155, 3297 (1995), Abstract
- Control of I kappa B-alpha proteolysis by site-specific, signal-induced phosphorylation: K. Brown, et al.; Science 267, 1485 (1995), Abstract
- Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons: N. Takei & Y. Endo; Brain Res. 652, 65 (1994), Abstract
- Potentiation of calcium- and caffeine-induced calcium release by cyclic ADP-ribose: H.C. Lee; J. Biol. Chem. 268, 293 (1993), Abstract — Full Text
- Contrasting effect of transforming growth factor type beta 1 (TGF-beta 1) on proliferation and interleukin-2 receptor expression in activated and rapidly cycling immature (CD3-CD4-CD8-) thymocytes: A. Dupuy d’Angeac, et al.; J. Cell. Physiol. 154, 44 (1993), Abstract
- Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitol: G. Kuznetsov, et al.; J. Biol. Chem. 267, 3932 (1992), Abstract — Full Text
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