Insulin receptor (human), (recombinant) (His-tag) (GST-tag)

INSR (Insulin receptor) (CD220), is a transmembrane receptor activated by insulin. INSR exists as a tetramer consisting of two alpha and two beta subunits linked by disulfide bonds. INSR associates with downstream mediators upon binding to insulin, including IRS1 (insulin receptor substrate 1) and phosphatidylinositol 3′-kinase (PI3K). INSR is expressed in the peripheral nerve, fibroblasts, kidney, liver, skin and striated muscle. Defects in INSR are associated with insulin resistance, Donohue syndrome, noninsulin-dependent diabetes mellitus, and Rabson-Mendenhall syndrome.