Home Shop Indirubin-5-sulfonic acid . sodium salt

Indirubin-5-sulfonic acid . sodium salt

ALX-270-296

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Inhibitor of CDK and GSK

Inhibitor of cyclin-dependent kinases (CDKs), with selectivity for CDK1/cyclin B (IC₅₀=55nM), CDK2/cyclin A (IC₅₀=35nM), CDK2/cyclin E (IC₅₀=150nM), CDK4/cyclin D1 (IC₅₀=300nM), CDK5/p35 (IC₅₀=65nM) and GSK-3β (IC₅₀=280nM).

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Product Details

Alternative Name	E226, Indirubin-5-sulphonate . Na
Appearance	Black powder.
Couple Target	CDK, GSK
Couple Type	Inhibitor
Formula	C₁₆H₉N₂O₅S . Na
Identity	Determined by 1H-NMR.
MW	341.3 . 23.0
Purity	≥95% (1H-NMR)
Solubility	Soluble in DMSO or water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibitor binding to active and inactive cdk2. the crystal structure of cdk2-cyclin a/indirubin-5-sulphonate: T.G. Davies, et al.; Structure (Camb) 9, 389 (2001), Abstract
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors?: S. Leclerc, et al.; J. Biol. Chem. 276, 251 (2001), Abstract — Full Text
Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells: D. Marko, et al.; Br. J. Cancer 84, 283 (2001), Abstract
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases: R. Hoessel, et al.; Nat. Cell. Biol. 1, 60 (1999), Abstract