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Indirubin-3′-monoxime

BML-CC207

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Inhibitor of CDK and GSK

A potent inhibitor of glycogen synthase kinase-3β (IC₅₀=22 nM). Also inhibits CDK1 (p34^cdc2; IC₅₀=180 nM) and CDK5 (IC₅₀=100 nM). It reversibly arrests asynchronous HBL-100 cells at G2. Induces apoptosis in the mammary carcinoma cell line MCF-7 (10 µM).

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Product Details

Appearance	Dark red solid.
CAS	160807-49-8
Couple Target	CDK, GSK
Couple Type	Inhibitor
Formula	C₁₆H₁₁N₃O₂
MW	277.3
Purity	≥98%
Solubility	Soluble in DMSO (6mg/ml) and ethanol (4mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

A Chemical Genetics Screen Reveals Influence of p38 Mitogen-Activated Protein Kinase and Autophagy on Phagosome Development and Intracellular Replication of Brucella neotomae in Macrophages: Kang, Y. S., Kirby, J. E., et al.; Infect. Immun. 87, (2019), Abstract
Increased aerobic glycolysis is important for the motility of activated VSMC and inhibited by indirubin-3´-monoxime: E.H. Heiss, et al.; Vascul. Pharmacol. 83, 47 (2016), Application(s): Cell culture, Abstract
Anti-mitotic properties of indirubin-3′-monoxime, a CDK/GSK-3 inhibitor: induction of endoreplication following prophase arrest: E. Damiens, et al.; Oncogene 20, 3786 (2001), Abstract
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer’s disease. A property common to most cyclin-dependent kinase inhibitors?: S. Leclerc, et al.; J. Biol. Chem. 276, 251 (2001), Abstract
Inhibition of cyclin-dependent kinase 1 (CDK1) by indirubin derivatives in human tumour cells: D. Marko, et al.; Br. J. Cancer 84, 283 (2001), Abstract
Indirubin, the active constituent of a Chinese antileukaemia medicine, inhibits cyclin-dependent kinases: R. Hoessel, et al.; Nat. Cell. Biol. 1, 60 (1999), Abstract

Last modified: May 29, 2024

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Indirubin-3′-monoxime

BML-CC207

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Handling & Storage

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