Imiquimod

ALX-420-039

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TLR7 ligand

Topical immune response modifier that inhibits angiogenesis. Up-regulates IL-18 and down-regulates MMP-9 through recognition of Toll-like receptor 7 (TLR7) and subsequent activation of MyD88-dependent pathway.

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Product Details

Alternative Name	1-(2-Methylpropyl)-1H-imidazo[4,5-c]quinolin-4-amine, R-837
Appearance	White to off-white powder.
CAS	99011-02-6
Couple Target	TLR, TLR7
Couple Type	Ligand
Formula	C₁₄H₁₆N₄
MW	240.3
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (3mg/ml) or dimethyl formamide; slightly soluble in water (warm to 37°C, vortex); insoluble in 100% ethanol.
Technical Info / Product Notes	Stimulation of TLR7 can be achieved with 1-10µg/ml of the compound for 6 to 24 hours.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for up to 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months when stored at -20°C.
Handling	After reconstitution, prepare aliquots and store at -20°C.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Serotonin 2A Receptor Attenuates Psoriatic Inflammation by Suppressing IL-23 Secretion in Monocyte-derived Langerhans Cells: Lee, Y., Tan, Y. F., et al.; Research Square , (2025)
The Local Activation of Toll-like Receptor 7 (TLR7) Modulates Colonic Epithelial Barrier Function in Rats: J. Estevez & V. Martinez; Int. J. Mol. Sci. 24, 1254 (2023), Abstract
TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons: L. Maatouk, et al.; Nat. Commun. 9, 2450 (2018), Abstract — Full Text
Poly (I: C) and imiquimod induced immune responses and their effects on the survival of olive flounder (Paralichthys olivaceus) from viral haemorrhagic septicaemia: S. Avunje, et al.; Fish Shellfish Immunol. 17, 338 (2017), Abstract
Tamoxifen downregulates MxA expression by suppressing TLR7 expression in PBMCs of males infected with HCV: I.O. Fawzy, et al.; J. Med. Virol. 86, 1113 (2014), Abstract
TLR7-expressing cells comprise an interfollicular epidermal stem cell population in murine epidermis: Yin, C., Zhang, T., et al.; Sci. Rep. 4, 5831 (2014), Abstract
Cathepsin K is involved in development of psoriasis-like skin lesions through TLR-dependent Th17 activation: T. Hirai, et al.; J. Immunol. 190, 4805 (2013), Abstract
Progesterone suppresses interferon signaling by repressing TLR-7 and MxA expression in peripheral blood mononuclear cells of patients infected with hepatitis C virus: S.S. Tayel, et al.; Arch. Virol. 158, 1755 (2013), Abstract
Differential regulation of splenic CD8- dendritic cells and marginal zone B cells by Notch ligands: C. Sekine, et al.; Int. Immunol. 21, 295 (2009), Abstract
Imiquimod as an antiangiogenic agent: V.W. Li, et al.; J. Drugs Dermatol. 4, 708 (2005), Abstract

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Imiquimod

ALX-420-039

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Imiquimod

ALX-420-039

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