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Cell permeable inhibitor of necrosis. Selectively blocks oxidative stress-induced necrotic cell death (~3µM IM-54 prevented ~50% cell death in HL60 cells exposed to 100µM H2O2). Does not protect against etoposide-induced apoptosis or display antioxidant properties. Does not affect S6K1 and PKC kinase activities at concentrations of 50µM.
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| Regulatory Status |
RUO – Research Use Only |
|---|
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| Alternative Name | (+)-3,3’,4’,5,7-Flavanpentol . H2O |
|---|---|
| CAS | 225937-10-0 |
| Purity | ≥98% (HPLC) |
| Alternative Name | EGCG, (2R,3R)-2-(3,4,5-Trihydroxyphenyl)-3,4-dihydro-1[2H]-benzopyran-3,5,7-triol 3-(3,4,5-trihydroxybenzoate) |
|---|---|
| CAS | 989-51-5 |
| Couple Type | Inhibitor |
| Purity | ≥98% (HPLC) |
| Alternative Name | (Z)-4-[1-(p-(Dimethylaminoethoxy)phenyl)-2-phenyl-1-butenyl]phenol |
|---|---|
| CAS | 68047-06-3, 65213-48-1 |
| Purity | ≥98% (UHPLC) |
| Alternative Name | (±)-Dihydroquercetin, (±)-3,3′,4′,5,7-Pentahydroxyflavanone, Taxifoliol, Distylin, Catechin hydrate |
|---|---|
| CAS | 17654-26-1 |
| Purity | ≥95% (HPLC) |