IM-12

BML-WN102

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GSK-3β inhibitor (IC₅₀=53nM (enzymatic), 3.8µM (cellular)). The compound significantly increases β-catenin levels, leads to TCF-induction and promotes neuronal differentiation in human neural progenitor cells via activation of canonical Wnt signaling.

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Product Details

Alternative Name	3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Appearance	Orange solid.
CAS	1129669-05-1
Couple Target	GSK
Couple Type	Inhibitor
Formula	C₂₂H₂₀FN₃O₂
MW	377.4
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (25 mg/ml) or in 100% ethanol (5 mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Store as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Short Term Storage	-20°C
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Generation of induced pluripotent stem cells from Bornean orangutans: Li, C. J., Chang, C. C., et al.; Front Cell Dev Biol 11, 1331584 (2024), Abstract
Induction of primordial germ cell-like cells from common marmoset embryonic stem cells by inhibition of WNT and retinoic acid signaling: Shono, M., Kishimoto, K., et al.; Sci. Rep. 13, 3186 (2023), Abstract
Recapitulating early human development with 8C-like cells: X. Yu, et al.; Cell Rep. 39, 110994 (2022), Abstract
Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells: T.X.A. Pham, et al.; Cell Stem Cell 29, 1346 (2022), Abstract
Hominoid-Specific Transposable Elements and KZFPs Facilitate Human Embryonic Genome Activation and Control Transcription in Naive Human ESCs: Pontis, J., Planet, E., et al.; Cell Stem Cell 24, 724 (2019), Abstract
Pluripotent state transitions coordinate morphogenesis in mouse and human embryos: Shahbazi, M. N., Scialdone, A., et al.; Nature 552, 239 (2017), Abstract
Isolation and cultivation of naive-like human pluripotent stem cells based on HERVH expression: Wang, J., Singh, M., et al.; Nat. Protoc. 11, 327 (2016), Abstract
Novel indolylmaleimide acts as GSK3ß inhibitor in human neural progenitor cells: A.-C. Schmole, et al.; Bioorg. Med. Chem. 18, 6785 (2010), Abstract

Last modified: May 29, 2024

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IM-12

BML-WN102

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Handling & Storage

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