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Ilimaquinone

BML-G435

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ADP-ribosylation factor inhibitor

Displays antimicrobial, anti-HIV and anti-inflammatory properties. Induces complete and reversible breakdown of Golgi membranes. Inhibits the association of β-COP and ADP-ribosylation factor to Golgi membranes, but unlike BFA, does not induce retrograde transport of Golgi enzymes into ER or cause random fusion of successive Golgi cisternae. Interacts with methylation enzymes. Shows anticancer activity.

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Product Details

Alternative Name	3-[(Decahydro-1β,2β,4αβ-trimethyl-5-methylene-1-naphthyl)methyl]-2-hydroxy-5-methoxybenzoquinone
Appearance	Yellow oil.
CAS	71678-03-0
Couple Target	ADP-ribosylation factor
Couple Type	Inhibitor
Formula	C₂₂H₃₀O₄
MW	358.5
Purity	≥98% (TLC)
Solubility	25mg/ml soluble in DMSO or 100% ethanol.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Solutions can be stored at -20°C for up to 3 months.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Ilimaquinone, a marine sponge metabolite, displays anticancer activity via GADD153-mediated pathway: P.H. Lu, et al.; Eur. J. Pharmacol. 556, 45 (2007), Abstract
Interaction of the smooth endoplasmic reticulum and mitochondria: J.G. Goetz & I.R. Nabi; Biochem. Soc. Trans. 34, 370 (2006), Review, Abstract
Ilimaquinone inhibits gap-junctional communication prior to Golgi fragmentation and block in protein transport: V. Cruciani, et al.; Exp. Cell Res. 287, 130 (2003), Abstract
Natural products with anti-HIV activity from marine organisms: L.A. Tziveleka, et al.; Curr. Top. Med. Chem. 3, 1512 (2003), Review, Abstract
Interactions of (-)-ilimaquinone with methylation enzymes: implications for vesicular-mediated secretion: H.S. Radeke, et al.; Chem. Biol. 6, 639 (1999), Abstract
Complete vesiculation of Golgi membranes and inhibition of protein transport by a novel sea sponge metabolite, ilimaquinone: P.A. Takizawa, et al.; Cell 73, 1079 (1993), Abstract
Microtubule independent vesiculation of Golgi membranes and the reassembly of vesicles into Golgi stacks: B. Veit, et al.; J. Cell. Biol. 122, 1197 (1993), Abstract
Ilimaquinone, a sesquiterpenoid quinone from a marine sponge: R.T. Luibrand, et al.; Tetrahedron 35, 609 (1979)

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Ilimaquinone

BML-G435

Product Details

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