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Interleukin 31 (IL-31) is an immunoregulatory cytokine that is expressed by activated type 2 T helper (Th2) cells. IL-31 signals through a heterodimer receptor consisting of the IL-31 Receptor A (IL-31RA) and the oncostatin M receptor (OSMR). IL-31 promotes allergic reactions and inflammatory skin diseases.
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Figure 1: Human IL-31 induced activation of STAT in U-87MG cells.
| Regulatory Status |
RUO – Research Use Only |
|---|
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| Alternative Name | OX40, TNFRSF 4 |
|---|---|
| Purity | ≥95% (SDS-PAGE) |
| Source | Produced in HEK 293 cells. The cysteine-rich region of human CD134 (OX40) (aa 29-214) is fused to the Fc portion of human IgG1. |
| Alternative Name | OX40L, TNFSF 4, CD252 |
|---|---|
| Source | Produced in HEK 293 cells. The extracellular domain of human CD134L (OX40L) (aa 52-183) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag. |
| Alternative Name | 4-1BB, TNFRSF 9 |
|---|---|
| Purity | ≥95% (SDS-PAGE) |
| Source | Produced in HEK 293 cells. The cysteine-rich region of human CD137 (4-1BB) (aa 1-186) is fused to the Fc portion of human IgG1. |
| Alternative Name | 4-1BBL, TNFSF 9 |
|---|---|
| Purity | ≥85% (SDS-PAGE) |
| Source | Produced in HEK 293 cells. The extracellular domain of human CD137L (aa 49-254) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag. |