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Interleukin-3 (IL-3) is a cytokine produced by activated T cells and mast cells. IL-3 is able to induce the differentiation of hematopoietic stem cells to precursor cells of myeloid lineage (erythrocytes, megakaryocytes, granulocytes, dendritic cells and monocytes). IL-3 also has functions in the nervous system and appears to be important in several chronic inflammatory diseases.
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Figure 1: Mouse IL-3 Bioactivity Data. Serial dilutions of mouse IL-3, starting at 0.350ng/ml, were added to Baf/3 cells. After 41 hours cell proliferation was measured and the linear portion of the curve was used to determine the ED50. The ED50 for this lot of mouse IL-3 was 0.3-0.47ng/ml. This value is comparable to the expected range of less than 0.5ng/ml.
| Regulatory Status |
RUO – Research Use Only |
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| Alternative Name | Interleukin-3, MCGF, Multi-CSF, HCGF, P-cell stimulation factor |
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| Purity | ≥95% (Reducing and Non-reducing SDS-PAGE) |
| Source | Produced in E. coli. Non-glycosylated protein, containing 134 amino acids. |