IL-2Rα (CD25) Recombinant monoclonal antibody (Rabbit IgGκ)

Interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2R subunit alpha, IL-2-RA, TAC antigen, p55

Flow Cytometry, FUNC, IF, IHC, WB

Basiliximab

Liquid. In PBS containing 0.02% Proclin 300.

Rabbit

Basiliximab was prepared by immunizing BALB/c mice with CTC 16 cells.

IgGκ

Protein A affinity purified.

Human

Recognizes human IL-2R and binds to the epitope E¹¹⁶RIYHFV¹²² within the extracellular domain of the CD25 subunit. Binding is abolished when 2 or more residues within the epitope are mutated. This epitope overlaps with the interaction site of CD25 and IL-2. CD25 is found in the high-affinity IL-2R (αβγc) – T cells only express CD25 upon activation. IL-2 binding to IL-2R on T cells modulates proliferation and differentiation.

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

P01589

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