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IL-21 is a cytokine identified in human and mouse that shows significant homology to IL-2, IL-4, and IL-15. The receptor for IL-21 (IL-21R) also termed NILR for novel interleukin receptor) is a member of the class I cytokine receptor family. IL-21R forms a complex with the common cytokine receptor gamma chain, gammac, and mediates IL-21 signaling via the JAK-Stat pathway. IL-21 is expressed in activated T-cells, as well as HL-60 and THP-1 cell lines. IL-21 plays a role in the proliferation and maturation of NK, B- and T-cell populations.
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Western blot analysis of IL-21 receptor expression in human Raji cell lysate with IL-21 Receptor antibody at 1µg/ml.
Immunohistochemistry analysis of IL-21 receptor in rat lung with IL-21 receptor antibody at 10µg/ml.
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RUO – Research Use Only |
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