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Interleukin 21 (IL-21) is normally expressed by activated CD4+ T cells. The IL-21 receptor activates the JAK/STAT signaling pathway and is expressed on T, B, and natural killer (NK) cells. IL-21 cooperates with IL-4 for the production of multiple antibody classes in B cells. IL-21 has pleiotropic effects on the proliferation, differentiation, and effector functions of B, T, NK, and dendritic cells.
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Figure 1: Serial dilutions of Human IL-21 (starting at 30 ng/mL) were added to ANBL-6 cells. After 84 hours, cell proliferation was measured and the linear portion of the curve can be used to calculate the ED50.
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RUO – Research Use Only |
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| Alternative Name | Interferon-λ-1, IL-29, Interleukin-29 |
|---|---|
| Purity | ≥98% (SDS-PAGE gel & HPLC) |
| Source | Produced in E.coli. |
| Alternative Name | IL-1RI, Interleukin-1 receptor type I, CD121a |
|---|---|
| Purity | ≥90% (SDS-PAGE) |
| Source | Produced in HEK 293 cells. Human IL-1RI (interleukin-1 receptor type I) (aa 21-336) is fused to the Fc portion of human IgG1. |
| Alternative Name | Interleukin-10, Cytokine synthesis inhibitory factor, CSIF |
|---|---|
| Purity | ≥98% (SDS-PAGE gel & HPLC) |
| Source | Produced in E.coli. |
| Alternative Name | Interleukin-10, Cytokine synthesis inhibitory factor, CSIF |
|---|---|
| Purity | ≥98% (SDS-PAGE gel & HPLC) |
| Source | Produced in E.coli. |