IL-1β (rat), ELISA kit

• Sensitive – use less precious sample per test
• Higher throughput – test up to 40 samples in duplicate in less than 4 hours
• Quantitative – obtain statistically significant results and compare data between multiple experiments
• Ready-to-use – pre-coated plates save time and reduce errors

The IL-1β (rat), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in < 4 hours.

The interleukin-1 (IL-1) cytokine family consists of IL-1α, IL-1β, and IL-1Rα (receptor antagonist) which are expressed primarily by endothelial cells and activated macrophages. IL-1α and IL-1β elicit pro-inflammatory cytokine production and cellular activation, and are the primary mediators of hypothalamic regulation that results in fever. IL-1α and IL-1βsignals are transmitted via a dual subunit IL-1 receptor composed of IL-1R1 and the IL-1 receptor accessory protein (IL-1RAcP). IL-1RAcP is vital to IL-1 signaling, as it recruits the IL-1 receptor-associated kinase (IRAK) to the receptor complex, initiating NF-κB pathway activation.