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Interleukin-19 (IL-19) is produced by B cells and monocytes. IL-19 binds the interleukin 20 receptor complex to activate STAT3 signaling. IL-19 induces IL-6 and tumor necrosis factor alpha (TNF-α) expression in monocytes, and promotes T helper 2 cell-mediated immune responses. IL-19 production is up-regulated in resting monocytes following granulocyte-macrophage colony-stimulating factor (GM-CSF) or lipopolysaccharide (LPS) stimulation.
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Last modified: May 29, 2024