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Interleukin 15 (IL-15) is a widely expressed proinflammatory cytokine that is structurally and functionally related to interleukin 2 (IL-2). IL-15 signals through JAK kinases to activate STAT3, STAT5, and STAT6 transcription factors. IL-15 regulates the activation of T cells, neutrophils, and macrophages, and is a stimulatory cytokine promoting dendritic cell function. IL-15 expression is dysregulated in chronic inflammatory disorders, including rheumatoid arthritis, psoriasis, and pulmonary inflammatory diseases.
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Figure 1: Serial dilutions of Human IL-15 (starting at 1 ng/mL) were added to CTLL-2 cells with other needed cytokines and stimuli. After 65 hours, cell viability was measured and the linear portion of the curve can be used to calculate the ED50.
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RUO – Research Use Only |
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