IL-1β (human), ELISA kit

• Sensitive – quantify down to 1 pg/mL
• Efficient – only 50 µl diluted sample required saving precious materials
• Specific – no cross-reactivity with related cytokines
• Results from up to 40 samples in duplicate in just 3 hours
• Ready-to-use reagents and pre-coated plates reduce errors and save your time

The IL-1β (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in < 3 hours. Absorbance is read at 450 nm. Quantify 1 pg/mL IL-1β with lot sample volume needed saving you precious sample.

The interleukin-1 (IL-1) cytokine family consists of IL-1α, IL-1β, and IL-1Rα (receptor antagonist) which are expressed primarily by endothelial cells and activated macrophages. IL-1α and IL-1β elicit pro-inflammatory cytokine production and cellular activation, and are the primary mediators of hypothalamic regulation that results in fever. IL-1α and IL-1βsignals are transmitted via a dual subunit IL-1 receptor composed of IL-1R1 and the IL-1 receptor accessory protein (IL-1RAcP). IL-1RAcP is vital to IL-1 signaling, as it recruits the IL-1 receptor-associated kinase (IRAK) to the receptor complex, initiating NF-κB pathway activation.