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IKK-NBD peptide

BML-P607

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NF-κB inhibitor

The peptide consists of two domains – an antennapedia homeodomain that confers cell permeability and the T735 to E745 region of IKKβ which is the NEMO binding domain (NBD). It is a selective inhibitor of NFκB activation. Blocks interaction of NEMO (an IKB complex regulatory protein) with the IκB kinase complex. The peptide (100 µM) inhibits E-selectin expression in human umbilical vein endothelial cells treated with TNFα and inhibits LPS-induced nitric acid release from a macrophage cell line In an experimental mouse model of acute inflammation, IKK-NBD peptide (topically applied) inhibited PMA induced ear inflammation. Sold under license from Vanderbilt University

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Product Details

Appearance	Lyophilized solid
MW	3694.0
Purity	≥95% (HPLC)
Sequence	Asp-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Thr-Ala-Leu-Asp-Trp-Ser-Trp-Leu-Gln-Thr-Glu
Solubility	Soluble in DMSO (20mM). Note: This peptide will precipitate when added to tissue culture medium, even to 100µM. However, enough will remain in solution to enter many cell types.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Ethanol Decreases Inflammatory Response in Human Lung Epithelial Cells by Inhibiting the Canonical NF-kB-Pathway: K. Mors, et al.; Cell. Physiol. Biochem. 43, 17 (2017), Abstract — Full Text
Electroacupuncture Could Regulate the NF-κB Signaling Pathway to Ameliorate the Inflammatory Injury in Focal Cerebral Ischemia/Reperfusion Model Rats: Qin, W. Y., Luo, Y., et al.; Evid. Based Complement. Alternat. Med. 2013, 924541 (2013), Reactant(s): Rat, Abstract
Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex: M. J. May et al.; Science 289, 5484 (2000), Abstract
Identification of Grb2 as a novel binding partner of tumor necrosis factor (TNF) receptor I: E. Hildt et al.; J. Exp. Med. 189, 1707 (1999), Abstract
Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation: S. Yamaoka et al.; Cell 93, 1231 (1998), Abstract

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IKK-NBD peptide

BML-P607

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

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