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Idarubicin . hydrochloride

ALX-380-260

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Topoisomerase IIα inhibitor

More potent, lipophilic and antineoplastic analog of daunorubicin. DNA-damaging effect includes DNA oxidation and methylation, DNA intercalation, inhibition of DNA synthesis, induction of DNA strand breaks and delay of cell cycle progression. Inhibitor of topoisomerase IIα. Produces endonucleolytic cleavage and is a marker of apoptosis.

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Product Details

Alternative Name	Idamycin, DMDR, 4-Demethoxydaunorubicin
Appearance	Orange crystalline solid.
CAS	57852-57-0
Couple Target	Topoisomerase
Couple Type	Inhibitor
Formula	C₂₆H₂₇NO₉ . HCl
Identity	Determined by IR.
MI	14: 4886
MW	497.5 . 36.5
Purity	≥98% (HPLC)
RTECS	HB7877000
Solubility	Soluble in water or methanol.
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Repair of idarubicin-induced DNA damage: A cause of resistance?: D.C. Dartsch & F. Gieseler; DNA Repair (Amst) 6, 1618 (2007), Abstract
A comparison of the in vitro genotoxicity of anticancer drugs idarubicin and mitoxantrone: J. Blasiak, et al.; Acta Biochim. Pol. 49, 145 (2002), Abstract — Full Text
Study of apoptosis-related responses of leukemic blast cells to in vitro anthracycline treatment: M.A. Belaud-Rotureau, et al.; Leukemia 14, 1266 (2000), Abstract
Antitumor activity of idarubicin, a derivative of daunorubicin, against drug sensitive and resistant P388 leukemia: T. Tsuruo, et al.; Anticancer Res. 13, 357 (1993), Abstract
Idarubicin (4-demethoxydaunorubicin). A preliminary overview of preclinical and clinical studies: F. Ganzina, et al.; Invest. New Drugs 4, 85 (1986), Review, Abstract

Last modified: May 29, 2024

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Idarubicin . hydrochloride

ALX-380-260

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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