ICRF-193

BML-GR332

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Topoisomerase inhibitor

A topoisomerase II inhibitor that does not cause DNA damage. Induces apoptosis in several cell lines including K562 and Molt-4 cells. Induces a G2 checkpoint that is associated with an ATR-dependent inhibition of polo-like kinase 1 (plk1) activity and a decrease in cyclin B1 phosphorylation.

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Product Details

Alternative Name	Meso-4,4′-(3,2-butanediyl)-bis(2,6-piperazinedione)
Appearance	Off-white to pale yellow solid.
CAS	21416-88-6
Couple Target	Topoisomerase
Couple Type	Inhibitor
Formula	C₁₂H₁₈N₄O₄
MW	282.3
Purity	≥95% (HPLC)
Solubility	Soluble in DMSO (4mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

RAD52 and ERCC6L/PICH have a compensatory relationship for genome stability in mitosis: Osia, B., Merkell, A., et al.; PLoS Genet. 20, e1011479 (2024), Abstract
Genome-Wide CRISPR Screens Reveal ZATT as a Synthetic Lethal Target of TOP2-Poison Etoposide That Can Act in a TDP2-Independent Pathway: Park, J. M., Zhang, H., et al.; Int. J. Mol. Sci. 24, (2023), Abstract
Mitotic tethering enables inheritance of shattered micronuclear chromosomes: Trivedi, P., Steele, C. D., et al.; Nature 618, 1049 (2023), Abstract
Mitotic tethering enables en masse inheritance of a shattered micronuclear chromosome: Trivedi, P., Steele, C. D., et al.; bioRxiv , (2022)
Chk1 and Wee1 kinases coordinate DNA replication, chromosome condensation, and anaphase entry: Fasulo, B., Koyama, C., et al.; Mol. Biol. Cell 23, 1047 (2012), Abstract
ATR enforces the topoisomerase II-dependent G2 checkpoint through inhibition of Plk1 kinase: P. B. Deming, et al.; J. Biol. Chem. 277, 36832 (2002), Abstract — Full Text
The catalytic DNA topoisomerase II inhibitor dexrazoxane (ICRF-187) induces differentiation and apoptosis in human leukemia K562 cells: B. B. Hasinoff, et al.; Mol. Pharmacol. 59, 453 (2001), Abstract — Full Text
Decreased thymosin beta4 in apoptosis induced by a variety of antitumor drugs: K. Iguchi, et al.; Biochem. Pharmacol. 57, 1105 (1999), Abstract

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Last modified: June 16, 2025

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ICRF-193

BML-GR332

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