Ibuprofen

BML-EI164

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COX inhibitor

Selective cyclooxygenase (COX) inhibitor (IC₅₀=14.9 µM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency (ID₅₀=8.9-14 and 7.2-8.2 µM respectively; data are for (S) isomer). Clinically useful NSAID. Inhibits the neutrophil-dependent edema response of rabbit skin to C5a/PGE₂.

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Product Details

Alternative Name	α-Methyl-4-(2-methylpropyl)benzeneacetic acid, (±)-2-(4-Isobutylphenyl)propionic acid
Appearance	White solid.
CAS	15687-27-1
Couple Target	COX
Couple Type	Inhibitor
Formula	C₁₃H₁₈O₂
MI	14: 4881
MW	206.3
Purity	≥99% (HPLC)
Solubility	Soluble in ethanol (25mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

APP processing in human pluripotent stem cell-derived neurons is resistant to NSAID-based γ-secretase modulation: Mertens, J., Stüber, K., et al.; Stem Cell Reports 1, 491 (2013), Abstract
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs: E.A. Meade, et al.; J. Biol. Chem. 268, 6610 (1993), Abstract
Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition: M. Rampart & T.J. Williams; Biochem. Pharmacol. 35, 581 (1986), Abstract
Differential effects of anti-inflammatory drugs on lipoxygenase and cyclo-oxygenase activities of neutrophils from a reverse passive Arthus reaction: R.F. Myers & M.I. Siegel; Biochem. Biophys. Res. Commun. 112, 586 (1983), Abstract

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Ibuprofen

BML-EI164

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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