IBA1 recombinant monoclonal antibody (031)

The anti-IBA1 antibody is a highly specific and sensitive tool for detecting IBA1 (Ionized Calcium-Binding Adapter Molecule 1), a key protein expressed in microglia and macrophages. This antibody is optimized for use in immunohistochemistry (IHC), immunofluorescence (IF), and ELISA, making it an essential tool for studying microglial activation, neuroinflammation, and immune responses in the central nervous system.

IBA1 (Ionized Calcium-Binding Adapter Molecule 1) is a cytoplasmic protein highly expressed in microglia, the resident immune cells of the central nervous system (CNS), as well as in macrophages. It is a member of the EF-hand calcium-binding protein family and plays a crucial role in microglial activation, phagocytosis, and cell migration in response to injury or disease. IBA1 is widely used as a specific marker for microglia in studies of neuroinflammation and neurodegeneration. Its upregulation is associated with the activation of microglia during pathological conditions such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, and stroke. IBA1 also participates in cytoskeletal reorganization, enabling microglia to adapt to the dynamic demands of the CNS environment.