Home Shop Hygromycin B (sterile-filtered solution in PBS)

Hygromycin B (sterile-filtered solution in PBS)

ALX-380-306

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Protein synthesis inhibitor

Antibiotic. Inhibits growth of prokaryotic and eukaryotic microorganisms and mammalian cells. Inhibits protein synthesis at the translocation step on the 70S ribosome and causes misreading of the mRNA. Penetrates cells that have been permeabilized by virus infection, hence it can act as an effective antiviral agent.

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Product Details

Alternative Name	O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine
Appearance	Liquid. In PBS.
CAS	31282-04-9
Formula	C₂₀H₃₇N₃O₁₃
MI	14: 4852
MW	527.5
Purity	≥90% (HPLC)
Purity Detail	Sterile filtered.
RTECS	WK2130000
Source	Isolated from Streptomyces hygroscopicus.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Working hygromycin solutions (≤2mg/ml) are stable for up to 1 month when stored at +4°C.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature – Dangerous Good

Regulatory Status	RUO – Research Use Only

In situ neutralization of the genotoxicity of pathogenic gut bacteria with the polyketide synthase island: Li, J., Yang, S., et al.; Research Square , (2024)
The subset of peroxisomal tail-anchored proteins do not reach peroxisomes via ER, instead mitochondria can be involved: Somborac, T., Lutfullahoglu Bal, G., et al.; PLoS One 18, e0295047 (2023), Abstract
HMBA ameliorates obesity by MYH9- and ACTG1-dependent regulation of hypothalamic neuropeptides: S. Park, et al.; EMBO Mol. Med. 15, e18024 (2023), Abstract
Yeast Smy2 and its human homologs GIGYF1 and -2 regulate Cdc48/VCP function during transcription stress: M.H. Lehner, et al.; Cell Rep. 41, 111536 (2022), Abstract
KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4: Kumar, A., Lyu, Y., et al.; Cell Rep. 39, 110788 (2022), Abstract
GSK3B induces autophagy by phosphorylating ULK1: H.Y. Ryu, et al.; Exp. Mol. Med. 53, 369 (2021), Abstract
Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits: Jung, S., Choe, S., et al.; Autophagy 16, 512 (2020), Abstract
CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis: An, H. K., Chung, K. M., et al.; Autophagy 16, 1598 (2020), Abstract
Fluorescence-based ATG8 sensors monitor localization and function of LC3/GABARAP proteins: Stolz, A., Putyrski, M., et al.; EMBO J. 36, 549 (2017), Abstract
Clr-a: A Novel Immune-Related C-Type Lectin-like Molecule Exclusively Expressed by Mouse Gut Epithelium: E. Rutkowski, et al.; J. Immunol. 198, 916 (2017), Abstract

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