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Hygromycin B (liquid)

ALX-380-059

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Antibiotic and antiviral

Antibiotic with high activity. Inhibits growth of prokaryotic and eukaryotic microorganisms and mammalian cells. Inhibits protein synthesis at the translocation step on the 70S ribosome and causes misreading of the mRNA. Penetrates cells that have been permeabilized by virus infection, hence it can act as an effective antiviral agent.

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Product Details

Alternative Name	O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine
Appearance	Dark brown solution.
CAS	31282-04-9
Formula	C₂₀H₃₇N₃O₁₃
MI	14: 4852
MW	527.5
Purity	≥80% (HPLC)
Quantity	1MU (1 million units); potency ≥385 U/mg solution.
RTECS	WK2130000
Source	Isolated from Streptomyces hygroscopicus.
Technical Info / Product Notes	Microbiological assay: 350’000-500’000U/ml. Solution has to be sterile-filtered before use. For ready-to-use sterile Hygromycin B solutions please refer to Prod. No. ALX-380-306 and ALX-380-309.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Bcl-2 family proteins contribute to apoptotic resistance in lung cancer multicellular spheroids: Yang, T. M., Barbone, D., et al.; Am. J. Respir. Cell Mol. Biol. 41, 14 (2009), Abstract
Hygromycin B inhibition of protein synthesis and ribosome biogenesis in Escherichia coli: S. M. McGaha & W. S. Champney; Antimicrob. Agents Chemother. 51, 591 (2007), Abstract
A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli ribosomes: M. C. Ganoza & M. C. Kiel; Antimicrob. Agents Chemother. 45, 2813 (2001), Abstract
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit:: D.E. Brodersen, et al.; Cell 103, 1143 (2000), Abstract
Induction of p53-independent apoptosis by hygromycin B: suppression by Bcl-2 and adenovirus E1B 19-kDa protein: G. Chen, et al.; Exp. Cell Res. 221, 55 (1995), Abstract
Antiviral effects of hygromycin B, a translation inhibitor nonpermeant to uninfected cells: J. C. Lacal & L. Carrasco; Antimicrob. Agents Chemother. 24, 273 (1983), Abstract
The Isolation of a Second Antibiotic from Streptomyces hygroscopicus: R. L. Mann & W. W. Bromer; J. Am. Chem. Soc. 80, 2714 (1958)

Related Products

Hygromycin B (sterile-filtered solution in PBS)

ALX-380-306

Protein synthesis inhibitor

17 citations

Alternative Name	O-6-Amino-6-deoxy-L-glycero-D-galacto-heptopyranosylidene-(1-2-3)-O-β-D-talopyranosyl(1-5)-2-deoxy-N3-methyl-D-streptamine
CAS	31282-04-9
Purity	≥90% (HPLC)

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Hygromycin B (liquid)

ALX-380-059

Product Details

Handling & Storage

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