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Human Type I Interferon Neutralizing Antibody Mixture

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Mixture of monoclonal and polyclonal antibodies directed against human Type 1 Interferons (IFNs) and Type 1 Receptor Subunit 2 (IFNAR2)
Effectively neutralizes biological activity of human IFN-alpha, IFN-beta, IFN-omega, IFN-kappa, and IFN-epsilon
Improves neutralization of multiple Type I IFNs often found in complex samples by employing a broadly neutralizing custom antibody cocktail
Unconjugated

Mixture of monoclonal and polyclonal antibodies directed against human Type I interferon receptor and several Type I interferons

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Alternative Name	IFN
Crossreactivity	No cross reactivity observed with the following human interferons: gamma, lambda 1, lambda 2, lambda 3; or mouse interferons: alpha, beta, gamma
Formulation	Supplied frozen in phosphate-buffered saline (PBS)
Purity Detail	Purified by a combination of Protein G affinity chromatography and other conventional chromatographical methods.
Species Reactivity	Human
Specificity	Blocks biological activity of human Type I interferons (alpha, beta, omega, kappa, epsilon)

Regulatory Status	RUO – Research Use Only

Innate antiviral responses against Shaan virus infection in HEK293, A549 and MARC-145 cells and limited role of viperin against Shaan virus replication: H.A. Lim, et al.; Heliyon 9, e22597 (2023), Abstract
SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response: S. Tsuji, et al.; Nat. Aging 2, 115 (2022), Abstract
Caspase-Mediated Regulation and Cellular Heterogeneity of the cGAS/STING Pathway in Kaposi’s Sarcoma-Associated Herpesvirus Infection: T. Tabtieng, ,et al.; mBio 13, e0244622 (2022), Abstract
Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon: R. Lundberg, et al.; Viruses 11, 1024 (2019), Abstract
Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease: P.A. Szabo, et al.; Nat. Commun. 10, 4706 (2019), Abstract

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