Human MC2R Reporter Assay System

• Clear, Reproducible Results
• All-Inclusive Assay Systems
• Exceptional Cell Viability Post-Thaw
• Consistent Results Lot to Lot

This is an all-inclusive cell-based luciferase reporter assay kit targeting the Human Melanocortin type 2 Receptor (MC2R, ACTHR). INDIGO’s MC2R reporter assay utilizes proprietary mammalian cells that have been engineered to provide constitutive expression of the MC2R. In addition to MC2R Reporter Cells, this kit provides two optimized media for use during cell culture and in diluting the user’s test samples, a reference agonist, Luciferase Detection Reagent, and a cell culture-ready assay plate. The principal application of this assay is in the screening of test samples to quantify any functional activity, either agonist or antagonist, that they may exert against MC2R. This kit provides researchers with clear, reproducible results, exceptional cell viability post-thaw, and consistent results lot to lot.

The melanocortin receptor system is important in the regulation of several physiological functions such as skin pigmentation, steroidogenesis, energy homeostasis, cardiovascular regulation, and inflammation. The melanocortin receptors are G-protein coupled receptors which bind in addition to adrenocorticotropic hormone (ACTH), one or more of the melanocortin stimulating hormones (α-MSH, β-MSH, or γ-MSH). These receptors have been targeted for drug development for the treatment of various skin disorders, skin cancer, obesity, inflammatory diseases and neurological disorders.