INDIGO’s assay utilizes proprietary human cells that have been engineered to provide constitutive expression of the Human Fibroblast Growth Factors 1 and 2 (FGFR1/2). FGFR1 and FGFR2 are both single-pass transmembrane receptors that contain respective extracellular ligand-binding domains, transmembrane domains, and intracellular tyrosine kinase domains.
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