Human Ephrin Type A receptor 2 Recombinant monoclonal antibody (1C1) (Rabbit IgGκ)

EphA2, Epithelial cell kinase, Tyrosine-protein kinase receptor ECK

ELISA, Flow Cytometry, IF, WB

1C1

Liquid. In PBS containing 0.02% Proclin 300.

Rabbit

1C1 was isolated after screening of a non-immunized human Fab phage library. Selection was based on the ability to bind soluble human recombinant EphA2 (residues 183-510). The Fab was subsequently converted to full length human IgG1.

IgGκ

Protein A affinity purified.

Human

Recognizes the N-termianal LBD (ligand-binding domain) region of the EphA2 ectodomain (IgG1 KD ~0.8 nM; Fab KD ~140 nM) and not to other related human Eph receptors such as EphA1, EphA2, and EphA4, or any EphB receptor family members.

This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG1 format, for improved compatibility with existing reagents, assays and techniques.

P29317

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