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HT-2 Toxin

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Mycotoxin

Trichothecene group mycotoxin. Induces apoptosis

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Alternative Name	15-Acetoxy-3α,4β-dihydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene
Appearance	White to slight yellow solid.
CAS	26934-87-2
Formula	C₂₂H₃₂O₈
MW	424.5
Purity	≥98% (TLC)
RTECS	YD0050000
Solubility	Soluble in 100% ethanol, DMSO or ethyl acetate. Slightly soluble in petroleum ether; poorly soluble in water.
Source	Semisynthetic, derived from T2 toxin from Fusarium tricinctum.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Mycotoxin occurrence on baled and pit silages collected in Co. Meath: C. McElinney, et al.; Irish J. Agr. Food. Res. 54, 87 (2015), Application(s): Liquid chromatography tandem mass spectrometry for Mycotoxin analysis, Full Text
A practical method for measuring deoxynivalenol, nivalenol, and T-2 + HT-2 toxin in foods by an enzyme-linked immunosorbent assay using monoclonal antibodies: T. Yoshizawa, et al.; Biosci. Biotechnol. Biochem. 68, 2076 (2004), Abstract — Full Text
Mechanisms involved in the induction of apoptosis by T-2 and HT-2 toxins in HL-60 human promyelocytic leukemia cells: J.A. Holme, et al.; Cell Biol. Toxicol. 19, 53 (2003), Abstract
Structure-function relationship of T-2 toxin and its metabolites in inducing thymic apoptosis in vivo in mice: Z. Islam, et al.; Biosci. Biotechnol. Biochem. 62, 1492 (1998), Abstract — Full Text

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Monoamine oxidase inhibitor

Alternative Name	4β,15-Diacetoxy-3α-hydroxy-8α-(3-methylbutyryloxy)-12,13-epoxytrichothec-9-ene
CAS	21259-20-1
Couple Type	Inhibitor
Purity	≥98% (TLC)

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