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Hsp47, also known as colligin and gp46, is an ER-resident collagen-specific stress glycoprotein involved in the synthesis and assembly of varoius collagens as a molecular chaperone. Hsp47 is a member of the serpin superfamily, but localizes to the ER via binding of its C-terminal RDEL sequence to KDEL receptors in the ER. Hsp47 binds procollagen co-translationally as it enters the ER, and dissociates prior to its secretion.
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SDS-PAGE Analysis. Lane 1: MW marker, Lane 2: 1.0 µg of purified Hsp47 (Prod. No. ADI-SPP-535)
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RUO – Research Use Only |
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