HOE-140

BML-NK104

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Bradykinin receptor ligand

A potent and selective bradykinin B2 antagonist. HOE-140 is a useful tool for discrimination of the physiological roles of bradykinin B2 versus B1 receptors. Displays a protective effect in myocardial reperfusion injury.

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Product Details

Alternative Name	Icatibant
Appearance	White solid.
CAS	130308-48-4
Couple Target	Bradykinin receptor
Couple Type	Ligand
Formula	C₅₉H₈₉N₁₉O₁₃S
Identity	Determined by MS.
MW	1304.5
Purity	≥95% (HPLC)
Sequence	D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-Tic-Oic-Arg
Solubility	Soluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Characterization of the Kallikrein-Kinin System Post Chemical Neuronal Injury: An In Vitro Biochemical and Neuroproteomics Assessment: A. Nokkari, et al.; PLoS One 10, e0128601 (2015), Application(s): Cell Culture, Abstract — Full Text
BK2 but not BK1 receptors mediating contractile response in human umbilical arteries: role of thromboxane A2: A. Tiritilli, et al.; Methods Find. Exp. Clin. Pharmacol. 26, 247 (2004), Abstract
Correlation between brain bradykinin receptor binding sites and cardiovascular function in young and adult spontaneously hypertensive rats: F. Cloutier, et al.; Br. J. Pharmacol. 142, 285 (2004), Abstract — Full Text
Bradykinin regulates cyclooxygenase-2 in rat renal thick ascending limb cells: J. A. Rodriguez, et al.; Hypertension 44, 230 (2004), Abstract — Full Text
Protective effect of bradykinin antagonist Hoe-140 during in vivo myocardial ischemic-reperfusion injury in the cat: R. Kumari, et al.; Regul. Pept. 115, 211 (2003), Abstract

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HOE-140

BML-NK104

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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