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HNMPA-(AM)₃

BML-EI248

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Insulin receptor inhibitor

HNMPA-(AM)₃ is a cell-permeable analog of HNMPA. It inhibits insulin receptor tyrosine kinase activity (IC₅₀=100 µM) and insulin-stimulated glucose oxidation in isolated rat adipocytes (IC₅₀=10 µM). It has no effect on PKA (at concs. up to 1 mM) or PKC (at concs. up to 420 µM). Inhibits both serine and tyrosine autophosphorylation by the human insulin receptor. Does not affect protein kinase C (PKC) or cAMP-dependent protein kinase (PKA).

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Product Details

Alternative Name	Hydroxy-2-naphthalenylmethylphosphonic acid tri-acetoxymethyl ester
Appearance	Colorless oil.
CAS	120944-03-8
Couple Target	Insulin receptor
Couple Type	Inhibitor
Formula	C₂₀H₂₃O₁₀P
Identity	Determined by NMR.
MW	454.4
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (>20mg/ml) or 100% ethanol (>20mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Solutions are stable for up to 3 months whn stored at -20°C. Avoid alkaline medium, pH>8.0
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Mechanism of action of camphoryl-benzene sulfonamide derivative on glucose uptake in adipose tissue: M.J.S. Frederico, et al.; J. Cell. Biochem. 119, 4408 (2018), Abstract
Insulin enhances striatal dopamine release by activating cholinergic interneurons and thereby signals reward: M.A. Stouffer, et al.; Nat. Commun. 6, 8543 (2018), Abstract — Full Text
A Small Insulinomimetic Molecule Also Improves Insulin Sensitivity in Diabetic Mice: S. Mukherjee, et al.; PLoS One 12, e0169809 (2017), Abstract — Full Text
Adaptive potentiation in rod photoreceptors after light exposure: McKeown, A. S., Kraft, T. W., et al.; J. Gen. Physiol. 143, 733 (2014), Abstract
Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor: K. Bantensperger et al.; PNAS 89, 7885 (1992), Abstract
Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells: R. Saperstein et al.; Biochemistry 28, 5694 (1989), Abstract

Last modified: May 29, 2024

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HNMPA-(AM)₃

BML-EI248

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