Helenalin

ALX-350-120

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NF-κB inhibitor

Potent anti-inflammatory and antineoplastic agent. Induces a CD95 death receptor-independent apoptosis even when the mitochondria protecting proteins Bcl-X_Lor Bcl-2 are overexpressed. Also an inhibitor of NF-κB.

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Product Details

Appearance	White to off-white solid.
CAS	6754-13-8
Couple Target	NF-kappaB
Couple Type	Inhibitor
Formula	C₁₅H₁₈O₄
Identity	Determined by NMR.
MW	262.3
Purity	≥97% (HPLC)
Solubility	Soluble in DMSO (10mg/ml) or 100% ethanol.
Source	Isolated from Arnica species.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Inhibiting IL-1 signaling pathways to inhibit catabolic processes in disc degeneration: Daniels, J., Binch, A. A., et al.; J. Orthop. Res. 35, 74 (2017), Abstract
Cox-2 Inhibition Protects against Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis via Akt-Dependent Enhancement of iNOS Expression: L. Pang, et al.; Oxid. Med. Cell. Longev. 2016, 3453059 (2016), Application(s): Cell treatment, rat cardiomyocytes , Abstract — Full Text
Upregulation of IL-17A/F from human lung tissue explants with cigarette smoke exposure: implications for COPD: Chang, Y., Al-Alwan, L., et al.; Respir. Res. 15, 145 (2014), Abstract
Th17-associated cytokines promote human airway smooth muscle cell proliferation: Chang, Y., Al-Alwan, L., et al.; FASEB J. 26, 5152 (2012), Abstract
Dibenzylbutyrolactone lignans from Forsythia koreana fruits attenuate lipopolysaccharide-induced inducible nitric oxide synthetase and cyclooxygenase-2 expressions through activation of nuclear factor-κb and mitogen-activated protein kinase in RAW264.7 cells: Lee, J. Y., Cho, B. J., et al.; Biol. Pharm. Bull. 33, 1847 (2010), Abstract
The anti-inflammatory sesquiterpene lactone helenalin inhibits the transcription factor NF-kappaB by directly targeting p65: G. Lyss, et al; J. Biol. Chem. 273, 33508 (1998), Abstract
Helenalin, an anti-inflammatory sesquiterpene lactone from Arnica, selectively inhibits transcription factor NF-kappaB: G. Lyss, et al.; J. Biol. Chem. 378, 951 (1997), Abstract
Constituents of Helenium species.XIII. The structure of Helenalin and Mexicanin A: W. Herz, et al.; JACS 85, 19 (1963)

Last modified: May 29, 2024

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Helenalin

ALX-350-120

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