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HDAC6 (human), (recombinant) (His-tag)

BML-SE508

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HDAC6 is a class II HDAC, a group defined by its member’s homology to the yeast HDAC HDA1. It is unique among human HDACs in that it contains two full deacetylase domains. A tubulin deacetylase, HDAC6 may act to promote autophagic clearing of huntingtin aggregates and retard HIV1 infection, but also to promote invasive motility in tumor cells.

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HDAC6 (human), (recombinant) (His-tag) SDS-PAGE — SDS-PAGE analysis: Lane 1: MW marker, Lane 2: 2µg HDAC6.

Product Details

Alternative Name	Histone deacetylase 6
Biological Activity	Active with various fluorogenic peptide substrates, including FLUOR DE LYS^® deacetylase substrate (Prod. No. BML-KI104) and FLUOR DE LYS^®-SIRT1 deacetylase substrate (Prod. No. BML-KI177).
Formulation	Liquid. In 50mM TRIS, pH 8.0, 138 mM NaCl and 10% glycerol.
Gene/Protein Identifier	NM_006044 (RefSeq)
MW	131 kDa
Purity Detail	Partially purified by single-step affinity chromatography and gel filtration.
Source	Produced in insect cells. Produced in a baculovirus expression system.
Specific Activity	≥1 U/µg. One U=1 pmol/min at 37°C, 100 µM, FLUOR DE LYS^®-SIRT1 deacetylase substrate (Prod. No. BML-KI177).
UniProt ID	Q9UBN7

Handling & Storage

Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells: M.A. Fischer, et al.; J. Adv. Res. , (2023), Abstract
Design, Synthesis, and biological evaluation of HDAC6 inhibitors based on Cap modification strategy: X. Li, et al.; Bioorg. Chem. 125, 105874 (2022), Abstract
Discovery of Novel Src Homology-2 Domain-Containing Phosphatase 2 and Histone Deacetylase Dual Inhibitors with Potent Antitumor Efficacy and Enhanced Antitumor Immunity: M. Liu, et al.; J. Med. Chem. 65, 12200 (2022), Abstract
Redox state and the sirtuin deacetylases are major factors that regulate the acetylation status of the stress protein NQO1: Siegel, D., Harris, P. S., et al.; Front. Pharmacol. 13, 1015642 (2022), Abstract
Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogramme the host immune response during persistent infection: Heim, C. E., Bosch, M. E., et al.; Nat. Microbiol. 5, 1271 (2020), Abstract
The Acetylation of Lysine-376 of G3BP1 Regulates RNA Binding and Stress Granule Dynamics: Gal, J., Chen, J., et al.; Mol. Cell. Biol. 39, (2019), Abstract
New 5-Aryl-Substituted 2-Aminobenzamide-Type HDAC Inhibitors with a Diketopiperazine Group and Their Ameliorating Effects on Ischemia-Induced Neuronal Cell Death: Y. Hirata, et al.; Sci. Rep. 8, 1400 (2018), Abstract
4-(1-Ethyl-4-anisyl-imidazol-5-yl)-N-hydroxycinnamide–A new pleiotropic HDAC inhibitor targeting Cancer cell signalling and cytoskeletal organisation: K. Mahal, et al.; Exp. Cell Res. 336, 263 (2015), Application(s): HDAC Assay, Abstract
Tasquinimod is an allosteric modulator of HDAC4 survival signaling within the compromised cancer microenvironment: J.T. Isaacs, et al.; Cancer Res. 73, 1386 (2012), Abstract
Tubulin acetylation alone does not affect kinesin-1 velocity and run length in vitro: W.J. Walter, et al.; PLoS One 7, e42218 (2012), Abstract — Full Text

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HDAC6 (human), (recombinant) (His-tag)

BML-SE508

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HDAC6 (human), (recombinant) (His-tag)

BML-SE508

Product Details

Handling & Storage

Related Products

FLUOR DE LYS® deacetylase substrate

BML-KI104

FLUOR DE LYS®-SIRT1 deacetylase substrate

BML-KI177

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

SDS

FLUOR DE LYS^®-SIRT1 deacetylase substrate