Home Shop HDAC3 (human), (recombinant) (His-tag)

HDAC3 (human), (recombinant) (His-tag)

BML-SE507

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HDAC3, although a class I HDAC and has been assigned to its own phylogenetic subclass and its caspase-dependent cleavage and relocation to the cytoplasm may be critical to the progression of apoptosis, implying an important role in pathways affecting heart disease.

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Product Details

Alternative Name	Histone deacetylase 3
Formulation	Liquid. In 50mM TRIS, pH 8.0, 138 mM NaCl and 10% glycerol.
Gene/Protein Identifier	NM_003883 (RefSeq)
MW	49 kDa
Purity Detail	Partially purified by single-step affinity chromatography and gel filtration.
Source	Produced in insect cells. Produced in a baculovirus expression system.
Specific Activity	≥0.7 U/µg. One U=1 pmol/min at 37°C, 100 µM, FLUOR DE LYS^®-SIRT1 deacetylase substrate (Prod. No. BML-KI177).
UniProt ID	O15379

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Long Term Storage	-80°C
Shipping	Dry Ice

Regulatory Status	RUO – Research Use Only

Novel hydroxamic acid derivative induces apoptosis and constrains autophagy in leukemic cells: M.A. Fischer, et al.; J. Adv. Res. , (2023), Abstract
Design, Synthesis, and biological evaluation of HDAC6 inhibitors based on Cap modification strategy: X. Li, et al.; Bioorg. Chem. 125, 105874 (2022), Abstract
CaMKII exacerbates heart failure progression by activating class I HDACs: Zhang, M., Yang, X., et al.; J. Mol. Cell. Cardiol. 149, 73 (2020), Abstract
Mitotic Activation of a Novel Histone Deacetylase 3-Linker Histone H1.3 Complex by Protein Kinase CK2: H. Patil, et al.; J. Biol. Chem. 291, 3158 (2016), Application(s): Pull down assay, Abstract — Full Text
Tasquinimod is an allosteric modulator of HDAC4 survival signaling within the compromised cancer microenvironment: J.T. Isaacs, et al.; Cancer Res. 73, 1386 (2012), Abstract
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis: M.M. Mihaylova, et al.; Cell 145, 607 (2011), Abstract — Full Text

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HDAC3 (human), (recombinant) (His-tag)

BML-SE507

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

Certificate of Analysis

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