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HA-100 . dihydrochloride

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Protein kinase inhibitor

Inhibitor of myosin light chain kinase, cAMP-dependent protein kinase (PKA) and protein kinase C (PKC).

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Alternative Name	1-(5-Isoquinolinylsulfonyl)piperazine . 2HCl
Appearance	Off-white lyophilized solid.
CAS	84468-24-6
Couple Target	MLCK, PKA, PKC
Couple Type	Inhibitor
Formula	C₁₃H₁₅N₃O₂S . 2HCl
MW	350.3
Purity	≥98% (HPLC)
Solubility	Soluble in water or DMSO.

Use/Stability	As indicated on product label or CoA when stored as recommended.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives: M. Hagiwara, et al.; Mol. Pharmacol. 32, 7 (1987), Abstract
Role of protein kinases in stimulation of human polymorphonuclear leukocyte oxidative metabolism by various agonists. Differential effects of a novel protein kinase inhibitor: C. Gerard, et al.; J. Clin. Invest. 77, 61 (1986), Abstract

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