H-9 . HCl

BML-EI195

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PKA inhibitor

An excellent affinity ligand for chromatographic purification of protein kinases. Inhibits protein kinases (K_i‘s: PKA=1.9 µM; PKC=18 µM; PKG=0.87 µM; MLCK=70 µM).

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Product Details

Alternative Name	N-(2-Aminoethyl)-5-isoquinolinesulfonamide . HCl
Appearance	White solid.
CAS	116970-50-4
Couple Target	PKA, PKG
Couple Type	Inhibitor
Formula	C₁₁H₁₃N₃O₂S . HCl
Identity	Determined by 1H-NMR.
MW	287.8
Purity	≥98% (TLC)
Solubility	Soluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored, as supplied, at 0-4°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	+4°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Stimulation of phosphorylation of rat brush-border membrane proteins by Escherichia coli heat-stable enterotoxin, cholera enterotoxin and cyclic nucleotides, and its inhibition by protein kinase inhibitors, isoquinolinesulfonamides: T. Hirayama, et al.; Microb. Pathog. 8, 421 (1990), Abstract
Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors.: M. Inagaki, et al.; Mol. Pharmacol. 29, 577 (1986), Abstract
N-(2-Aminoethyl)-5-isoquinolinesulfonamide, a newly synthesized protein kinase inhibitor, functions as a ligand in affinity chromatography. Purification of Ca2+-activated, phospholipid-dependent and other protein kinases.: M. Inagaki, et al.; J. Biol. Chem. 260, 2922 (1985), Abstract
Interaction of protein kinase C with membranes is regulated by Ca2+, phorbol esters, and ATP.: M. Wolf, et al.; J. Biol. Chem. 260, 15718 (1985), Abstract
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C: H. Hidaka, et al.; Biochemistry 23, 5036 (1984), Abstract

Last modified: May 29, 2024

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H-9 . HCl

BML-EI195

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Handling & Storage

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