Home Shop H-1152 . dihydrochloride

H-1152 . dihydrochloride

ALX-270-423

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ALX-270-423-M001 — 1 mg

$89.00

H-1152 . dihydrochloride quantity
ALX-270-423-M005 — 5 mg

$359.00

H-1152 . dihydrochloride quantity
ALX-270-423-M025 — 25 mg

$1,027.00

H-1152 . dihydrochloride quantity

ROCK inhibitor

A cell permeable, highly specific, potent and ATP-competitive inhibitor of Rho kinase (ROCK) (K_i=1.6nM). Exhibits a much weaker affinity for other serine/threonine kinases (K_i=630nM for PKA, 9.27mM for PKC and 10.1mM for MLCK). More potent and selective than Y-27632 (Prod. No. ALX-270-333). Inhibits the phosphorylation of MARCKS in cells stimulated by lysophosphatidic acid. Inhibits EP3-stimulated NO formation. Prevents fragmentation of apoptotic cells. Relieves neuropathic pain.

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Product Details

Alternative Name	H-1152P . 2HCl, (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]homopiperazine . 2HCl
Appearance	White to off-white solid.
CAS	451462-58-1
Couple Target	ROCK
Couple Type	Inhibitor
Formula	C₁₆H₂₁N₃O₂S . 2HCl
Identity	Identity determined by 1H-NMR and 13C-NMR.
MW	319.4 . 73.0
Purity	≥98% (TLC)
Solubility	Soluble in water.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light. Hygroscopic.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

LFA-1 and Kindlin-3 enable the collaborative transport of SLP-76 microclusters by myosin and dynein motors: K.P. Eidell, et al.; J. Cell Sci. 36, 258602 (2021), Abstract
Dysregulation in Actin Cytoskeletal Organization Drives Increased Stiffness and Migratory Persistence in Polyploidal Giant Cancer Cells: B. Xuan, et al.; Sci. Rep. 8, 11935 (2018), Abstract
A Rho signaling network links microtubules to PKD controlled carrier transport to focal adhesions: Eisler, S. A., Curado, F., et al.; Elife 7, (2018), Abstract
Sema3d controls collective endothelial cell migration by distinct mechanisms via Nrp1 and PlxnD1: M.J. Hamm, et al.; J. Cell Biol. 215, 415 (2016), Abstract — Full Text
Local and tissue-scale forces drive oriented junction growth during tissue extension: C. Collinet, et al.; Nat. Cell Biol. 17, 1247 (2015), Application(s): Cell Culture, Abstract
A self-organized biomechanical network drives shape changes during tissue morphogenesis: A. Munjal, et al.; Nature 524, 351 (2015), Application(s): Cell culture , Abstract
Actin-Mediated Gene Expression Depends on RhoA and Rac1 Signaling in Proximal Tubular Epithelial Cells: K. Giehl, et al.; PLoS One 10, e0121589 (2015), Application(s): Cell Culture, Abstract — Full Text
Distinct mesenchymal alterations in N-cadherin and E-cadherin positive primary renal epithelial cells: Keller, C., Kroening, S., et al.; PLoS One 7, e43584 (2012), Abstract
Rho kinase regulates fragmentation and phagocytosis of apoptotic cells: K.A. Orlando, et al.; Exp. Cell Res. 312, 5 (2006), Abstract
Regulation of the crossbridge cycle in vascular smooth muscle by cAMP signalling: G. Pfitzer, et al.; J. Muscle Res. Cell. Motil. 27, 445 (2006), Abstract

Related Products

Y-27632 . dihydrochloride

ALX-270-333

ROCK inhibitor

170 citations

Alternative Name	(R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide . 2HCl
CAS	129830-38-2
Couple Type	Inhibitor
Purity	≥98% (HPLC (UV))

ALX-270-333-M001 — 1 mg

$157.00

Y-27632 . dihydrochloride quantity
ALX-270-333-M005 — 5 mg

$250.00

Y-27632 . dihydrochloride quantity
ALX-270-333-M025 — 25 mg

$764.00

Y-27632 . dihydrochloride quantity

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H-1152 . dihydrochloride

ALX-270-423

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Handling & Storage

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