GYY 4137

ALX-430-163

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H₂S donor

Water-soluble, slow-releasing hydrogen sulfide (H₂S) donor. Shows vasodilator and antihypertensive activity in rats in both acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Inhibits LPS-induced release of various proinflammatory mediators (such as IL-1β, IL-6, TNF-α, nitric oxide (NO) and PGE2) in RAW264.7 cells. Increases the synthesis of the anti-inflammatory chemokine IL-10 through NF-κB, ATF-2 and HSP27 dependent pathways in RAW264.7 cells.

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Product Details

Alternative Name	4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt
Appearance	White solid.
CAS	106740-09-4
Formula	C₁₁H₁₅NO₂PS₂. C₄H₁₀NO
Identity	Identity determined by 1H-NMR.
MW	288.3 . 88.1
Purity	≥95%
Solubility	Soluble in water (30mg/ml) or DMSO (15mg/ml).
Source	Synthetic.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended.
Handling	Protect from light and moisture.
Long Term Storage	-20°C
Shipping	Blue Ice

Regulatory Status	RUO – Research Use Only

Systemic hydrogen sulfide administration partially restores normal alveolarization in an experimental animal model of bronchopulmonary dysplasia: Madurga, A., Mižíková, I., et al.; Am. J. Physiol. Lung Cell. Mol. Physiol. 306, L684 (2014), Abstract
Regulation of heart function by endogenous gaseous mediators-crosstalk between nitric oxide and hydrogen sulfide: Q.C. Yong, et al.; Antioxid. Redox Signal. 14, 2081 (2011), Abstract
The slow releasing H2S donor GYY 4137 exerts anti-thrombotic effects via a P-selectin dependent mechanism: E. Grambow, et al.; DGCH , (2011), Abstract
The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo: Z.W. Lee, et al.; PLoS One 6, e21077 (2011), Abstract — Full Text
The effect of hydrogen sulfide donors on lipopolysaccharide-induced formation of inflammatory mediators in macrophages: M. Whiteman, et al.; Antioxid. Redox Signal. 12, 1147 (2010), Abstract — Full Text
A novel hydrogen sulfide donor causes stomatal opening and reduces nitric oxide accumulation: M. Lisjak, et al.; Plant Physiol. Biochem. 48, 931 (2010), Abstract
GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat.: L. Li, et al.; Free Radic. Biol. Med. 47, 103 (2009), Abstract
Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.: L. Li et, al.; Circulation 117, 2351 (2008), Abstract — Full Text

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GYY 4137

ALX-430-163

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

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