GW5074

BML-EI307

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Raf inhibitor

Potent and selective cell permeable inhibitor of cRAF1 kinase (IC₅₀ = 9 nM) with 100-fold selectivity over CDK1, CDK2, c-src, ERK2, MEK, p38, Tie2, VEGFR2 and c-fm. A useful tool for assessing the involvement of the Ras/Raf-1/ERK pathway in various signaling pathways. Displays neuroprotective effects in vivo through a MEK-ERK and Akt-independent mechanism.

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Product Details

Alternative Name	5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone
Appearance	Yellow to orange solid.
CAS	220904-83-6
Couple Target	Raf
Couple Type	Inhibitor
Formula	C₁₅H₈Br₂INO₂
MW	520.9
Purity	≥98% (TLC)
Solubility	Soluble in DMSO (>25 mg/ml).

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stock solutions are stable for at least 6 months when stored at -20°C.
Handling	Protect from light. Keep under inert gas.
Long Term Storage	-20°C
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis: Kindrachuk, J., Ork, B., et al.; Antimicrob. Agents Chemother. 59, 1088 (2015), Abstract
Fibroblast growth factor-2 suppresses oridonin-induced L929 apoptosis through extracellular signal-regulated kinase-dependent and phosphatidylinositol 3-kinase-independent pathway: J. Huang, et al.; J. Pharmacol. Sci. 102, 305 (2006), Abstract
Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-kappaB, but not p38 MAPK, pathways: M.S. Chang, et al.; Cell Signal. 17, 299 (2005), Abstract
Bradykinin B2 receptor mediates NF-kappaB activation and cyclooxygenase-2 expression via the Ras/Raf-1/ERK pathway in human airway epithelial cells: B.C. Chen, et al.; J. Immunol. 173, 5219 (2004), Abstract
The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism: P.C. Chin, et al.; J. Neurochem. 90, 595 (2004), Abstract
The discovery of potent cRaf1 kinase inhibitors: K. Lackey, et al.; Bioorg. Med. Chem. Lett. 10, 223 (2000), Abstract

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GW5074

BML-EI307

Product Details

Handling & Storage

Datasheet, Manuals, SDS & CofA

Manuals And Inserts

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