GW-9662

BML-GR234

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PPAR ligand

Potent, selective and irreversible PPARγ antagonist. Blocks the PPARγ-induced differentiation of monocytes to osteoclasts by >90% at a dose of 0.1µM. Much more potent antagonist than BADGE (Prod. No. ALX-270-353). Can be used to antagonize the effects of PPARγ agonists in a variety of cell types.

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Product Details

Alternative Name	2-Chloro-5-nitrobenzanilide
Appearance	White to off-white solid.
CAS	22978-25-2
Couple Target	PPAR
Couple Type	Ligand
Formula	C₁₃H₉N₂O₃Cl
MW	276.7
MeltingPoint	155-157°C
Purity	≥98% (HPLC)
Solubility	Soluble in DMSO (50mg/ml), 100% ethanol (10mg/ml) or dimethyl formamide. Insoluble in water.
Technical Info / Product Notes	Note: Product is not sterile.

Handling & Storage

Use/Stability	As indicated on product label or CoA when stored as recommended. Stable for at least 1 year after receipt when stored at +20°C. Stock solutions are stable for up to 3 months at -20°C.
Long Term Storage	Ambient
Shipping	Ambient Temperature

Regulatory Status	RUO – Research Use Only

Halogenated bisphenol a analogues induce PPARγ-independent toxicity within human hepatocellular carcinoma cells: V. Cheng & D.C. Volz; Curr. Res. Toxicol. 3, 100079 (2022), Abstract
Cannabinoids Reduce Inflammation but Inhibit Lymphocyte Recovery in Murine Models of Bone Marrow Transplantation: I. Khuja, et al.; Int. J. Mol. Sci. 20, 668 (2019), Application(s): used to examine CBDs effect on proliferation of CD3 activated murine splenocytes, Abstract — Full Text
Ginsenoside Rb1 promotes browning through regulation of PPARγ in 3T3-L1 adipocytes: Q. Mu, et al.; Biochem. Biophys. Res. Commun. 291, 30581 (2015), Application(s): Antagonize the effects of PPARγ agonists, Abstract
Pharmacological manipulation of peroxisome proliferator-activated receptor γ (PPARγ) reveals a role for anti-oxidant protection in a model of Parkinson’s disease: Martin, H. L., Mounsey, R. B., et al.; Exp. Neurol. 235, 528 (2012), Abstract
Acute rosiglitazone treatment is cardioprotective against ischemia-reperfusion injury by modulating AMPK, Akt, and JNK signaling in nondiabetic mice: Morrison, A., Yan, X., et al.; Am. J. Physiol. Heart Circ. Physiol. 301, H895 (2011), Abstract
Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-gamma in human proximal renal tubular cells: Li, X., Kimura, H., et al.; Nephrol. Dial. Transplant. 22, 1041 (2007), Abstract
PPARgamma regulates the function of human dendritic cells primarily by altering lipid metabolism: Szatmari, I., Töröcsik, D., et al.; Blood 110, 3271 (2007), Abstract
15-Deoxy-{delta}12,14-prostaglandin j2 inhibits interleukin-1{beta}-induced nuclear factor-{kappa}b in human amnion and myometrial cells: mechanisms and implications: T.M. Lindström & P.R. Bennett; J. Clin. Endocrinol. Metab. 90, 3534 (2005), Abstract — Full Text
Peroxisome-proliferator-activated receptor gamma induces a clearance mechanism for the amyloid-beta peptide: Camacho, I. E., Serneels, L., et al.; J. Neurosci. 24, 10908 (2004), Abstract
PPAR gamma activators induce growth arrest and process extension in B12 oligodendrocyte-like cells and terminal differentiation of cultured oligodendrocytes: A.D. Roth, et al.; J. Neurosci. Res. 72, 425 (2003), Abstract

Last modified: May 29, 2024

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GW-9662

BML-GR234

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